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氯霉素分子印迹复合膜的制备及电化学

赵路2,杜江燕1,2*   

  1. (1.江苏省生物功能材料重点实验室，2.南京师范大学化学与材料科学学院 南京 210046)
  • 收稿日期:2011-11-02 修回日期:2011-12-27 出版日期:2012-10-10 发布日期:2012-10-10
  • 通讯作者: 杜江燕，教授; Tel/Fax:025-85891767; E-mail:dujiangyan@njnu.edu.cn; 研究方向：生物电化学
  • 基金资助:
    江苏高校优势学科建设工程江苏省新动力电池重点实验室资助项目

Fabrication of Chloramphenicol Molecular Imprinted Composite Film and Its Electrochemistry

ZHAO Lu2, DU Jiangyan1,2*   

  1. (1.Jiangsu Key Laboratory of Biofunctional Materials,2.College of Chemistry
    and Materials Science,Nanjing Normal University,Nanjing 210046,China)
  • Received:2011-11-02 Revised:2011-12-27 Published:2012-10-10 Online:2012-10-10

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摘要： 采用电化学聚合法合成了对氯霉素（CAP）有快速响应和高灵敏度的聚苯胺/聚吡咯分子印迹复合膜修饰电极。 通过微分脉冲伏安法、扫描电子显微镜对制备的分子印迹复合膜的电化学性质及表面形貌进行了表征。 结果表明，以铁氰化钾为电化学探针，该膜对CAP的测定电化学信号响应快速、灵敏度高、选择性和膜再生性能良好。 对CAP检测的线性范围为5.00×10-8～1.05×10-6 mol/L,检测限为2.09×10-9 mol/L。

关键词: 分子印迹复合膜, 电化学聚合, 电化学检测, 氯霉素, 苯胺, 吡咯

Abstract: A novel imprinted composite film electrochemical sensor was fabricated based on molecularly imprinted composite film for the determination of chloramphenicol(CAP). The imprinted composite film was prepared by electrochemical polymerization of pyrrole(PPY) and polyaniline(PAN) on the surface of stainless steel needle(SSN) electrode in the presence of CAP as a template. The morphology and electrochemical property of the film were characterized by SEM and differential pulse voltammetry with ferricyanide as an electrochemical probe, respectively. The film exhibited the good sensitivity, selectivity and the ability of regeneration. A linear relationship between the current of electrochemical probe and the concentration of CAP was found in the range of 5.00×10-8～1.05×10-6 mol/L with a detection limit of 2.09×10-9 mol/L.

Key words: molecular , impinted film, electrochemical polymerization, electrochemical detection, chloramphenicol, aniline, pyrrole

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