中华医学超声杂志

应用化学 ›› 2010, Vol. 27 ›› Issue (06): 664-668.DOI: 10.3724/SP.J.1095.2010.90541

• 研究论文 • 上一篇    下一篇

5-苄基-4-叔丁基-2-苄亚氨基噻唑的合成与杀菌活性

杨林涛1,覃智1,陈平2,胡艾希1*   

  1. (1.湖南大学化学化工学院 长沙 410082；2.长沙理工大学化学与生物工程学院 长沙)
  • 收稿日期:2009-08-19 修回日期:2009-10-30 出版日期:2010-06-10 发布日期:2010-06-10
  • 通讯作者: 胡艾希，男，教授，博士生导师; E-mail:axhu0731@yahoo.com.cn; 研究方向：药物化学
  • 基金资助:
    中央高校基本科研业务费专项资金(531107040010)资助项目

Synthesis and Fungicidal activity of 4-tert-butyl-5-Benzyl-2-Benzyliminothiazole

YANG Lin-Tao1, QIN Zhi1, CHEN Ping2, HU Ai-Xi1*   

  1. (1.College of Chemistry and Chemical Engineering,Hunan University,Changsha 410082;
    2.Institute of Chemistry and Biological Technology,Changsha University of Science & Technology,Changsha)
  • Received:2009-08-19 Revised:2009-10-30 Published:2010-06-10 Online:2010-06-10

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摘要：

5-苄基-4-叔丁基-2-氨基噻唑与水杨醛衍生物反应制备了12种5-苄基-4-叔丁基-2-苄亚氨基噻唑类新化合物。 初步测试了25种5-苄基-4-叔丁基-2-苄亚氨基噻唑的杀菌活性。 结果表明,化合物1a(500 mg/L)对水稻纹枯病菌抑制率为95%；化合物1i、1j、1l、1p、1q和1s(25 mg/L)对小麦赤霉病菌的抑制率分别为55.1%、55.1%、51.3%、51.5%、51.5%和51.5%；化合物1i、1l和1s(25 mg/L)对辣椒疫霉病菌抑制率分别为51.1%、51.9%和64.9%；化合物1h和1j(25 mg/L)对黄瓜灰霉病菌抑制率为53.1%和61.2%；化合物1t、1o和1r(25 mg/L)对油菜菌核病菌的抑制率分别为56.1%、56.1%和65.4%；化合物1w(25 mg/L)对烟草赤星病菌的抑制率为52.6%。

关键词: 苄基叔丁基苄亚氨基噻唑, 合成, 杀菌活性

Abstract:

Twelve new 5-benzyl-4-tert-butyl-2-benzyliminothiazoles were synthesized via the reacitions of 5-benzyl-4-tert-butylthiazol-2-amines with salicyladehyde derivatives. The bioassay of twenty five 4-tert-butyl-5-benzyl-2-benzyliminothiazoles were made. The results of preliminary bioassay show that the inhibition rate of compound 1a(500 mg/L) is 95% against R.solani; the inhibition rates of compounds 1i, 1j, 1l, 1p, 1q and 1s(25 mg/L) are 55.1%, 55.1%, 51.3%, 51.5%, 51.5% and 51.5% against G.zeae respectively; the inhibition rates of compounds 1i, 1l and 1s are 51.1%, 51.9% and 64.9% against P.capsici; the inhibition rates of compounds 1h and 1j(25 mg/L) are 53.1% and 61.2% against B.cinerea respectively; the inhibition rates of compounds 1t, 1o and 1r(25 mg/L) are 56.1%, 56.1% and 65.4% against S.sclerotiorum respectively; and the inhibition rate of compound 1w(25 mg/L) is 52.6% against A.alternata.

Key words: tert-butylbenzylbenzyliminothiazole, synthesis, Antibacterial activity

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