靛红亚胺参与构建手性3-氨基-2-吲哚酮骨架的研究进展

doi:10.11944/j.issn.1000-0518.2019.12.190170

摘要/Abstract

摘要：

手性3-氨基-2-吲哚酮骨架广泛存在于许多药物分子以及天然产物中,具有较高的药用价值。靛红亚胺参与的不对称反应是合成手性3-氨基-2-吲哚酮衍生物的直接途径。本文围绕着不对称aza-Henry反应、不对称环化反应及其他不对称反应3个方面,综述了靛红亚胺参与构建手性3-氨基-2-吲哚酮衍生物的研究进展并进行了展望。

关键词: 靛红亚胺, 不对称, Aza-Henry, 环化反应, 3-氨基-2-吲哚酮

Abstract:

The chiral 3-amino-2-oxindole skeletons are widely present in many drug molecules and natural products, and show high medicinal value. The asymmetric reaction involving of isatin-derived ketimines provides a direct access to chiral 3-amino-2-oxindole derivatives. In this paper, the recent progress on the asymmetric aza-Henry, cyclization and other asymmetric reactions for the construction of 3-amino-2-oxindoles skeleton with isatin-derived ketimines is reviewed and the future development is prospected.

Key words: isatin-derived ketimines, asymmetric, aza-henry, cyclization, 3-amino-2-oxindole

张俊伟,吴昊,陈哲,金瑛,姜英子. 靛红亚胺参与构建手性3-氨基-2-吲哚酮骨架的研究进展[J]. 应用化学, 2019, 36(12): 1343-1360.

ZHANG Junwei,WU Hao,CHEN Zhe,JIN Ying,JIANHG Yingzi. Recent Progress on the Construction of Chiral 3-Amino-2-oxindoles Skeleton with Isatin-Derived Ketimines as Reactants[J]. Chinese Journal of Applied Chemistry, 2019, 36(12): 1343-1360.

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