(R)-α-硫辛酸合成方法的研究进展

doi:10.11944/j.issn.1000-0518.2020.11.200151

摘要/Abstract

摘要： (R)-α-硫辛酸可用于预防和治疗糖尿病及相关并发症,也可以作为保健品使用,用途广泛,因而其高效合成方法长期以来受到广泛关注。目前,合成(R)-α-硫辛酸的方法主要有酶和化学方法催化的不对称合成、消旋体的手性拆分以及手性底物控制的不对称合成。本文将以此为分类标准,对目前所报道的(R)-α-硫辛酸合成方法进行总结归纳和展望。

关键词: 硫辛酸, 手性拆分, 不对称合成

Abstract: The methods for the effective synthesis of (R)-α-lipoic acid have been widely investigated since (R)-α-lipoic acid can be widely used for the treatment of diabetes and diabetic complications. It is also extensively used in health care products. Therefore, asymmetric synthesis of (R)-α-lipoic acid has attracted broad interests from the community of both academia and industry. To date, the reported routes for the synthesis of (R)-α-lipoic acid include asymmetric synthesis catalyzed by the enzymatic and chemical catalysts, chiral resolution, and chiral substrate-controlled synthesis. Based on this classification, this paper summarizes the advances of the methods for asymmetric synthesis of (R)-α-lipoic acid and predicts future prospects.

Key words: lipoic acids, chiral resolution, asymmetric synthesis

中图分类号:

O629.9

韩修, 康传清. (R)-α-硫辛酸合成方法的研究进展[J]. 应用化学, 2020, 37(11): 1236-1248.

HAN Xiu, KANG Chuanqing. Advances in Synthetic Methods of (R)-α-Lipoic Acid[J]. Chinese Journal of Applied Chemistry, 2020, 37(11): 1236-1248.

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