Research Progress of Artificial Water Channels Inspired by Aquaporin

doi:10.19894/j.issn.1000-0518.210484

Chinese Journal of Applied Chemistry ›› 2022, Vol. 39 ›› Issue (1): 99-109.DOI: 10.19894/j.issn.1000-0518.210484

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Research Progress of Artificial Water Channels Inspired by Aquaporin

HUAI Meng-Jiao,LIU Tao-Xue-Ting,JIANG Zhong-Yi()

School of Chemical Engineering and Technology，Tianjin University，Tianjin 300072，China

Received:2021-09-28 Accepted:2021-11-04 Published:2022-01-01 Online:2022-01-10
Contact: Zhong-Yi JIANG
About author:zhyjiang@tju.edu.cn
Supported by:
the National Natural Science Foundation of China(91934302);the Key K&D Project of Zhejiang Province(2021C03173)

Abstract

Abstract:

Based on the structure and functions of aquaporin （AQP）， bioinspired and biomimetic membranes that incorporate biological transport channels or their structure mimics have undergone a remarkable development over the last decade. By transplanting the mass transport properties of aquaporins， artificial water channels （AWC） exhibit both high permeability and selectivity. Through the in-depth analysis of AQP， with the aim of both high selectivity and high permeability in the artificial water channel， three types of effects including “gating effect”， “hydrophilic effect” and “queuing effect” are proposed. Then， we analyze and summarize the existing research work of bioinspired desalination membrane. Finally， it is pointed out that the above three effects explore novel paths to the ration design of artificial water channel on account of biomimeticism and bioinspiration philosophy.

Key words: Aquaporin, Biomimetic membrane of desalination, Gating effect, Hydrophilic effect, Queuing effect

CLC Number:

O629.7

HUAI Meng-Jiao, LIU Tao-Xue-Ting, JIANG Zhong-Yi. Research Progress of Artificial Water Channels Inspired by Aquaporin[J]. Chinese Journal of Applied Chemistry, 2022, 39(1): 99-109.

Figures/Tables 8

Fig.1 The scope of this review

Fig.2 The structure of AQP1［27-28］（a）side view of AQP monomer；（b）side and top view of the tetrameric AQP complex with the four monomers

Fig.3 Artificial water channel based on 3A size（a）Helical tube formed by zwitterionic coordination polymers［32］；（b）Imidazole I-quartets water channels［16］；（c）Aquafoldamer-based water channels［34］

Table 1 Pore size， water permeability and salt rejection of artificial water channels

人工水通道 AWC	孔道尺寸 Pore size/nm	单通道水通量（个H₂O/s） Water permeability per channel（H₂O/s）	离子排斥能力 Salt rejection
两性离子通道^［32］ Zwitterionic coordination polymers water channels	0.26	-	-
四聚体咪唑通道^［16-17］ Imidazole I?quartets water channels	0.26	1.5×10⁶	√
Aquafoldamer通道 Aquafoldamer?based water channels	0.28	2.2×10^8［37］	√
		1.6×10^9［34］	√
		3×10^9［35］	√
杂化芳烃（PAH［4］）通道簇^［36］ Peptide?appended hybrid ［4］ arene water channels	~0.3	>10⁹	√

Fig.4 helical pores assembled by dendritic dipeptides［44］

Fig.5 Comparison of the transport rate between channel 1 with alternating hydrophilic and hydrophobic channels and channel 2 with weaker action［35］

Fig.6 Arrangement of water molecules in （a） hydrophilic channel （b） hydrophobic channel（c） hydrophilic and hydrophobic water level point alternating channel［44］

Fig.7 The arrangement of water molecules in the artificial water channel（a）Helical tube formed by zwitterionic coordination polymers［32］；（b）Imidazole I-quartets water channels［16］；（c） Chemical and crystal structures of 1， encapsulating 1D chain of dichloromethane （CH2Cl2） or methanol （MeOH）90 molecules. And Chemical and crystal structures of 2， encapsulating the 1D chain of water or MeOH molecules［36］；（d） Different H-bonding patterns for water in the bulk state and CNTPs of different diameters［49］

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Research Progress of Artificial Water Channels Inspired by Aquaporin

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