Preparation and Properties of Oleanolic Acid-Alkanolamines Complexes

doi:10.3724/SP.J.1095.2014.30499

Chinese Journal of Applied Chemistry

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Preparation and Properties of Oleanolic Acid-Alkanolamines Complexes

YAN Jiawen, MA Zhenmao^*

(School of Chemistry and Materials Sciences,Nanjing Normal University,Nanjing 210023,China)

Received:2013-10-09 Revised:2013-11-30 Published:2014-07-10 Online:2014-07-10
Contact: Zhen-Mao MA

Abstract

Abstract: Complexes of oleanolic acid(OA) and alkanolamines(EAs)[Ethanolamine(MEA), diethanolamine(DEA) or triethanolamine(TEA)] were prepared by an ultrasonic method. The complexes were characterized by DSC, XRD, IR and Raman spectroscopy. It was found that the complexes is formed through the intermolecular force between OA and EAs rather than chemical bonding. The solubility of OA-EAs complexes is much higher than that of OA. The present study supplies a novel concept for the design of an efficient delivery system of OA.

Key words: oleanic acid, alkanolamines, ultrasound method, solubility

CLC Number:

O621.2

YAN Jiawen, MA Zhenmao*. Preparation and Properties of Oleanolic Acid-Alkanolamines Complexes[J]. Chinese Journal of Applied Chemistry, DOI: 10.3724/SP.J.1095.2014.30499.

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Preparation and Properties of Oleanolic Acid-Alkanolamines Complexes

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