Measurement of Crystallization Metastable Zone of Nitazoxanide Using the Laser Scattering Method

doi:10.3724/SP.J.1095.2011.00610

Chinese Journal of Applied Chemistry ›› 2011, Vol. 28 ›› Issue (09): 1063-1066.DOI: 10.3724/SP.J.1095.2011.00610

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Measurement of Crystallization Metastable Zone of Nitazoxanide Using the Laser Scattering Method

ZHAO Dishun^1*, LV Bin², KOU Cheng¹, YANG Jie¹, DONG Lanfen¹, ZHANG Yan¹

(1.College of Chemistry and Pharmaceutical Engineering;2.College of Sciences,
Hebei University of Science and Technology,Shijiazhuang 050018)

Received:2010-10-13 Revised:2010-12-09 Published:2011-09-10 Online:2011-09-10

Abstract

Abstract:

The saturated and supersaturated characteristics of nitazoxanide in DMF, DMSO, methanol and acetone at different temperatures were investigated by using the laser detection technique. The crystallization metastable zone widths of nitazoxanide were obtained at different temperatures in the above four solvents. The results indicated that the solubility, supersolubility and the metastable zone width of nitazoxanide enhance with increasing temperature. At the same temperature, the metastable zone width of nitazoxanide relations as follows:acetone＜DMSO＜methanol＜DMF.

Key words: nitazoxanide, solubility, supersolubility, metastable zone width

CLC Number:

O626.1

ZHAO Dishun1*, LV Bin2, KOU Cheng1, YANG Jie1, DONG Lanfen1, ZHANG Yan1. Measurement of Crystallization Metastable Zone of Nitazoxanide Using the Laser Scattering Method[J]. Chinese Journal of Applied Chemistry, 2011, 28(09): 1063-1066.

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Measurement of Crystallization Metastable Zone of Nitazoxanide Using the Laser Scattering Method

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