Chinese Journal of Applied Chemistry

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Efficient Synthesis of Bis(indolyl)methanes Under Solvent-free and Catalyst-free Conditions

LIU Xiongwei1, PAN Bowen1, GUO Fengmin1, CAO Yu2, LIU Xiongli1, ZHOU Ying1*   

  1. (1.Guizhou Province Chinese Medicine and Ethnic Medicine Creation Engineering Center,
    College of Life Sciences,Guizhou University,Guiyang 550025,China;
    2.Skin Department,Hospital Affiliated to Guiyang Medical College,Guiyang 550025,China)
  • Received:2013-08-28 Revised:2013-12-04 Published:2014-07-10 Online:2014-07-10

Abstract: Without the addition of catalysts and solvents, 15 known bis(indolyl)alkane compounds were synthesized under mild conditions from substituted indoles and substituted benzaldehydes in 65%~91% yields. The mechanism of this condensation reaction was discussed and the relationship between reaction speed and substituent groups was described. All the compounds synthesized were confirmed by 1H NMR, 13C NMR and IR analysis.

Key words: Aldehyde, bisindolylalkane, indole

CLC Number: