Abstract: 5-Chlorosalicylaldehyde-2-aminoethanol-copper(Ⅱ) was synthesized using 5-chlorosalicylaldehyde, 2-aminoethanol and cupric chloride as precursors under microwave irradiation. The product was characterized by IR spectra, elemental analysis and single X-ray crystallography study. The title complex crystallizes in the monoclinic space group P21/n. Cell parameters:a=0.49793(6) nm, b=1.7037(2) nm, c=1.07120(12) nm, β=94.579(3)°, F(000)=470, Z=2, V=0.905(8) nm3, Dc=1.689 mg/m3, R[I＞2σ(I)], R1=0.0624, ωR2=0.1555. The Cu(Ⅱ) adopts a square planar configuration coordinated by two nitrogen atoms and two oxygen atoms from two Schiff bases. The antibacterial(B.subtilis, S.aureus, S.faecalis, P.aeruginosa, E.coli and E.cloacae) activities of the compounds were assayed by MTT(3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) method. It showed favorable antimicrobial activity with minimal inhibitory concentrations(MICs) of 12.25, 25, 12.5, 12.5, 6.25 and 6.25 mg/L against B.subtilis, S.aureus, S.faecalis, P.aeruginosa, E.coli and E.cloacae, respectively.

Key words: chlorosalicylaldehyde-aminoethanol-copper(Ⅱ), microwave-assisted, crystal structure, antibacterial activity