Chinese Journal of Applied Chemistry

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Synthesis and Temperature Sensitivity of N-isopropylacryamide Copolymers with Glucose Pendant

LOU Shaofeng1, ZHANG Hua1, ZHANG Peipei1, TIAN Liqiang1, NIE Huali1, QUAN Jing1,2*, ZHU Limin1*   

  1. (1.College of Chemistry,Chemical Engineering and Biotechnology;2.Key Laboratory of Science & 
    Technology of Eco-Textile of Ministry of Education,Donghua University,Shanghai 201620,China)
  • Received:2012-06-20 Revised:2012-07-26 Online:2013-04-10 Published:2013-04-10

Abstract: The polymerisable glucose derivates, 6-O-vinyladipoyl-D-glucose was sythesized by chemoenzymatic transesterification, the novel thermosensitive glycopolymers, poly(N-isopropylacryamide-co-6-O-vinyladipoyl-D-glucose)(NIPAAm-co-OVAG) were fabricated free radical copolymerization from N-isopropylacryamide(NIPAAm) and 6-O-vinyladipoyl-D-glucose(OVAG). The structures and properties of the copolymers were confirmed by 1H NMR, UV-Vis absorbance and GPC. Moreover, the hydrodynamic diameter and gyration radius of the poly(OVAG-co-NIPAAm) in aqueous solution were studied by laser light scattering. Finally, we found that the poly(OVAG-co-NIPAAm) chains exist in aqueous as nearly spherical nanoparticles with diameter around 60 nm and the lower critical solution temperature(LCST) increased from 32 ℃ of PNIPAAm homopolymer to 39 ℃.

Key words: Self-aggregation, thermosensitive glycopolymer, enzyme catalyzed synthesis, double-hydrophilic

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