Chinese Journal of Applied Chemistry ›› 1998, Vol. 0 ›› Issue (5): 39-42.

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Synthesis of Uniconazole-P

Liao Lianan, Cui Houxiang, Chen Mingde, Zhang Hongkui, Guo Qizhen   

  1. Department of Chemistry, Xiamen University, Xiamen 361005
  • Received:1997-11-28 Revised:1998-06-30 Published:1998-10-10 Online:1998-10-10

Abstract: 4-Chlorophenyl acetaldelyde reacting with α-triazolylpinacolone in the presence of KF/Al2O3/PEG4000 will produce 85% vinyltriazolyl ketone(Ⅱ) with E/Z =0.65; Ⅱ is then isomerized by light to a yield of 92% E-Ⅱ with E/Z ≥99/1. It is then reduced in the presence of certain charge transfer catalyst V by KBH4 to 92% Uniconazole-P with ee of 30%.

Key words: Uniconazole-P, synthesis, Knoevenagel reaction, asymmetric reduction