Abstract:

Twelve new 5-benzyl-4-tert-butyl-2-benzyliminothiazoles were synthesized via the reacitions of 5-benzyl-4-tert-butylthiazol-2-amines with salicyladehyde derivatives. The bioassay of twenty five 4-tert-butyl-5-benzyl-2-benzyliminothiazoles were made. The results of preliminary bioassay show that the inhibition rate of compound 1a(500 mg/L) is 95% against R.solani; the inhibition rates of compounds 1i, 1j, 1l, 1p, 1q and 1s(25 mg/L) are 55.1%, 55.1%, 51.3%, 51.5%, 51.5% and 51.5% against G.zeae respectively; the inhibition rates of compounds 1i, 1l and 1s are 51.1%, 51.9% and 64.9% against P.capsici; the inhibition rates of compounds 1h and 1j(25 mg/L) are 53.1% and 61.2% against B.cinerea respectively; the inhibition rates of compounds 1t, 1o and 1r(25 mg/L) are 56.1%, 56.1% and 65.4% against S.sclerotiorum respectively; and the inhibition rate of compound 1w(25 mg/L) is 52.6% against A.alternata.

Key words: tert-butylbenzylbenzyliminothiazole, synthesis, Antibacterial activity