Abstract:

An efficient method for the synthesis of fluoroaromatics with tetramethylammonium fluoride(TMAF_anh.) as fluorination agent via the fluorodenitration reaction was reported. Fluoroaromatics were obtained from TMAFanh. and nitroaromatics by simply stirring them together at 80~100 ℃ for 1~5 h in an anhydrous solution of DMF in 19.4%~99.0% yields. The nucleophilic fluorinating method has the advantages of mild reaction conditions, high yields, easy workup and no phenol or ether sideproducts were detected in the reaction.

Key words: tetramethylammonium fluoride, nitroaromatics, fluoroaromatics, fluorodenitration