A novel method for synthesis of 3β-Hydroxyandrost-4-en-6, 17-dione

doi:10.3724/SP.J.1095.2010.90429

Chinese Journal of Applied Chemistry ›› 2010, Vol. 27 ›› Issue (05): 615-617.DOI: 10.3724/SP.J.1095.2010.90429

• Original Articles • Previous Articles Next Articles

A novel method for synthesis of 3β-Hydroxyandrost-4-en-6, 17-dione

ZHANG Xiao-Jia, CUI Jian-Guo*, LI Ying, FAN Jian-Chun

(Department of Chemistry and Life Science,Guangxi Teachers Education University,Nanning 530001)

Received:2009-06-29 Revised:2009-08-31 Published:2010-05-10 Online:2010-05-10

Abstract

Abstract:

Dehydroepiandrosterone was oxidized with PCC to obtain androst-4-en-3,6,17-rione(2), which was then submitted to reduction with NaBH4 in the presence of Co2+ to obtain 3β-hydroxyandrost-4-en-6,17-dione(3), a nonandrogenic aromatase inhibitor. Compared with literature′s methods, this method shortens the reaction steps and improves the reaction yield. The structure of compound 3 was characterized by NMR and IR.

Key words: dehydroepiandrosterone, 3β-hydroxyandrost-en-dione, synthesis

CLC Number:

O629.2

ZHANG Xiao-Jia, CUI Jian-Guo*, LI Ying, FAN Jian-Chun. A novel method for synthesis of 3β-Hydroxyandrost-4-en-6, 17-dione[J]. Chinese Journal of Applied Chemistry, 2010, 27(05): 615-617.

[1]	Jia-Zheng LI, Shu-Zhong HE. Research Progress of Total Synthesis of Polygalolides [J]. Chinese Journal of Applied Chemistry, 2023, 40(5): 615-624.
[2]	Zhen-Bang LIU, Shuo ZHANG, Yu BAO, Ying-Ming MA, Wei-Qi LIANG, Wei WANG, Ying HE, Li NIU. Progress of Application Research on Cheminformatics in Deep Learning [J]. Chinese Journal of Applied Chemistry, 2023, 40(3): 360-373.
[3]	Yang LIU, Hai-Bao ZHANG, Qiang CHEN. Optimization of Process Parameters for Ammonia Synthesis by Nanosecond Pulsed Dielectric Barrier Discharge Plasma [J]. Chinese Journal of Applied Chemistry, 2023, 40(2): 268-276.
[4]	Rong CAO, Jie-Zhen XIA, Man-Hua LIAO, Lu-Chao ZHAO, Chen ZHAO, Qi WU. Theoretical Research Progress of Single Atom Catalysts in Electrochemical Synthesis of Ammonia [J]. Chinese Journal of Applied Chemistry, 2023, 40(1): 9-23.
[5]	Dan MENG, Kai-Yuan ZHENG, Shan-Shan CHEN, Zhao-Long ZHUO, Li-Li WANG. Preparation and Luminescence Properties of Silicon and Nitrogen Co⁃doped Carbon Dots Phosphors [J]. Chinese Journal of Applied Chemistry, 2022, 39(11): 1766-1773.
[6]	WU Zhi-Qiang, HAN Xin-Ning, LIU Yang, WANG Gang, ZHAN Hai-Juan, LIU Wan-Yi. Research Progress on Synthesis of Bis(indolyl)methanes under Aqueous or Solvent-free Catalysis [J]. Chinese Journal of Applied Chemistry, 2021, 38(8): 881-896.
[7]	BO Chun-Hui, JIANG Wei-Jia, WANG Yu-Gao, SHI Li-Hong, DONG Chuan. Research Progress on Synthesis of Coal-based Carbon Quantum Dots [J]. Chinese Journal of Applied Chemistry, 2021, 38(7): 767-788.
[8]	LIU Yang, ZHANG Hai-Bao, CHEN Qiang. Research Progress on Ammonia Synthesis Using Low Temperature Plasma [J]. Chinese Journal of Applied Chemistry, 2021, 38(6): 622-636.
[9]	LIU Yu-Ting, SUN Jia-Xi, YIN Da-Wei. Research Progress on the Synthesis and Application of Ferroncene-based Polymers [J]. Chinese Journal of Applied Chemistry, 2021, 38(4): 343-366.
[10]	XIE Zhi-Qi, ZHANG Ting, LI Ying-Wei, WANG Zhou-Jun, DAI Fei, ZHANG Rui-Rui, LIU Rui-Xia. Effect of Synthesis Conditions of Vanadium Phosphorus Oxygen (VPO) Catalyst on Catalytic Performance for Selective Oxidation of Butane [J]. Chinese Journal of Applied Chemistry, 2021, 38(4): 414-421.
[11]	GAO Feng, XU Zi-Di, GUAN Chun-Qian, WANG Yan, ZANG Yun-Hao, QU Jiang-Ying. Green Controllable Synthesis of Sulfur/Graphene Aerogel and Performance of Lithium Sulfur Battery [J]. Chinese Journal of Applied Chemistry, 2021, 38(4): 439-446.
[12]	BI Yipiao, GONG Xue, YANG Fa, RUAN Mingbo, SONG Ping, XU Weilin. Polyvalent MnO_x/C Electrocatalyst for Highly Efficient Nitrogen Reduction Reaction [J]. Chinese Journal of Applied Chemistry, 2020, 37(9): 1048-1055.
[13]	ZHANG Baohua, SHI Lanxiang. One-Pot Synthesis of Aryl/Heteroaryl Aminomethylene Bisphosphonates [J]. Chinese Journal of Applied Chemistry, 2020, 37(8): 877-882.
[14]	MENG Yating, JIAO Yuan, ZHANG Yuan, GAO Yifang, LU Wenjing, LIU Yang, DONG Chuan. Synthesis of Red Emission Fluorescent Carbon Dots and Its Application for Detection of Persulfate [J]. Chinese Journal of Applied Chemistry, 2020, 37(6): 719-725.
[15]	CHEN Lin, MIN Man, LIN Jidi. Synthesis and Antioxidation Activity of 3-Amino-7,8-dimethoxycoumarin and Its Derivatives [J]. Chinese Journal of Applied Chemistry, 2020, 37(12): 1420-1425.

A novel method for synthesis of 3β-Hydroxyandrost-4-en-6, 17-dione

PDF

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments