Chinese Journal of Applied Chemistry ›› 2010, Vol. 27 ›› Issue (01): 102-106.

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Preparation of Molecularly Imprinted Polymer Films Modified Silica gel and its Extraction Application

LI Yong1, ZHOU Wen-Hui2, YANG Huang-Hao2*, WANG Xiao-Ru1,2   

  1. (1.College of Chemistry and Chemical Engineering,Ocean University of China,Qingdao;
    2.The First Institute of Oceanography,SOA,Qingdao 266061)
  • Received:2009-01-15 Revised:2009-05-08 Online:2010-01-10 Published:2010-01-10


This paper describes the use of surface initiated reversible addition-fragmentation chain transfer (RAFT) polymerization to graft thin molecularly imprinted polymer (MIP) films from the silica gel particles (MIP-Silica). The grafted imprinted polymer film was characterized by elemental analysis and nitrogen adsorption analysis. The MIP-silica prepared in this study had improved mass-transfer properties compared with MIPs prepared by conventional bulk polymerization. In addition, this paper also proved that the MIP-Silica can be used as the sorbent in solid-phase extraction to determine theophylline in blood serum with satisfactory recovery. Furthermore, the MIP-silica can also be applied in HPLC and capillary electrochromatography.

Key words: molecularly imprinted polymer, Reversible Addition-Fragmentation chain Transfer, silica gel, theophylline

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