Synthesis and Application of Carboxymethyl Chitosan Magnetic Nanoparticles

Chinese Journal of Applied Chemistry ›› 2010, Vol. 27 ›› Issue (01): 87-91.

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Synthesis and Application of Carboxymethyl Chitosan Magnetic Nanoparticles

LI Yu-Hui, PENG Ting-Ting, ZHANG Li, OUYANG Li, XIE Jing-Ji, SU Xiao-Li, MA Ming*

(MOE,Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research,
Hunan Normal University,Changsha 410081)

Received:2009-01-12 Revised:2009-03-06 Published:2010-01-10 Online:2010-01-10
About author: Corresponding author: Ming Ma, female, Ph. D, professor; E-mail: mingma@hunnu.edu.cn; Research field: Separation and analytical chemistry

Abstract

Abstract:

Carboxymethyl chitosan magnetic nanoparticles (CMCS-OA-Fe₃O₄NPs) were prepared by a two-step method, i.e., synthesizing nanosized Fe₃O₄ in the presence of oleic acid (OA-Fe₃O₄NPs), then directly coating the OA-Fe₃O₄ NPs with carboxymethyl chitosan in aqueous solution. The prepared CMCS-OA-Fe₃O₄ NPs were characterized with transmission electron microscopy (TEM), vibrating sample magnetometer (VSM), Fourier transform infrared spectrometry (FT-IR) and simultaneous thermal analyzer (STA), respectively. The CMCS-OA-Fe₃O₄ NPs were found to be regularly spherical with carboxyl on their surface, roughly a diameter of 10 nm. The CMCS-OA-Fe₃O₄ NPs exhibited good paramagnetism and stability. The drug loading and the sustained-release property of the CMCS-OA-Fe₃O₄NPs for adriamycin (ADM) in phosphate buffer solution (PBS, pH 7.4) were studied. High drug loading (91.8 mg/g) of CMCS-OA-Fe₃O₄ NPs and obvious sustained-release effect in vitro for ADM were reached. The results indicate that CMCS-OA-Fe₃O₄NPs may be used as the magnetic-targeted nano drug carrier for the treatment of tumour.

Key words: carboxymethylated chitosan, magnetic nanoparticles, drug release, adriamycin

CLC Number:

0636.1

LI Yu-Hui, PENG Ting-Ting, ZHANG Li, OUYANG Li, XIE Jing-Ji, SU Xiao-Li, MA Ming. Synthesis and Application of Carboxymethyl Chitosan Magnetic Nanoparticles[J]. Chinese Journal of Applied Chemistry, 2010, 27(01): 87-91.

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Synthesis and Application of Carboxymethyl Chitosan Magnetic Nanoparticles

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