Abstract:

A novel diselenide porphyrins dimmers was synthesized using 5(4- hydroxylphenyl)-10,15,20- triphenyl porphyrin and selenium as raw materials. The structure of the novel porphyrin was confirmed by 1H NMR, IR, UV, and MS. The interaction between the porphyrin and bovine serum albumin (BSA) was investigated by fluorescence spectrum, and the binding constant was calculated according to the data: Ksv＝3.35×104 L/mol。 The results show that the novel porphyrin has a powerful ability of quenching the intrinsic fluorescence of BSA .

Key words: diselenide porphyrin dimmer,bovine serum albumin,fluorescence spectrum,static quenching