Chinese Journal of Applied Chemistry ›› 2019, Vol. 36 ›› Issue (12): 1376-1386.DOI: 10.11944/j.issn.1000-0518.2019.12.190066

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Iron Corrole Complexes: DNA-Binding and Anti-tumor Activity

SHI Leia*(),YANG Wenconga,SHEN Qia,YIN Weia,HUO Zhaohuia,SI Lipingb,LIU Haiyangc   

  1. aDepartment of Chemistry,Guangdong University of Education,Guangzhou 510303,China
    bSchool of Materials Science and Energy Engineering,Foshan University,Guangdong Foshan 528000,China
    cKey Laboratory of Functional Molecular Engineering of Guangdong Province,South China University of Technology,Guangzhou 510640,China
  • Received:2019-03-14 Accepted:2019-06-25 Published:2019-12-01 Online:2019-12-10
  • Contact: SHI Lei
  • Supported by:
    Supported by the Higher Education Teaching Reform Project in Guangdong Province(2018), the Open Fund Project of Foshan University(2018), the Special Funds for Guangdong University Students' Climbing Plan, College Students Innovation and Entrepreneurship Training Program, the Teaching Quality and Teaching Reform in Guangdong Second Normal University(2018), and the Innovation and Strong School Funding from Guangdong University of Education-Foundation for Distinguished Young Talents in Higher Education of Guangdong(No.2016KQNCX112)

Abstract:

10-(4-Phenothiazine)-5,15-bis(pentafluorophenyl)corrolatoiron (2-Fe) was synthesized. Complex 2-Fe displays high cytotoxic activity against human lung adenocarcinoma (A549) cell lines. Flow cytometry detected 2-Fe arrested the cell cycle in the S and G2 phase in the presence of H2O2 and apoptotic rate was 63.76%. Hoechst-33342 staining showed considerable morphological changes in nuclear chromatin and mitochondrial transmembrane potential dropped respectively. Complex 2-Fe could interact with DNA via an outside binding mode and trigger 1O2 generation.

Key words: corrole, phenothiazine, DNA, cytotoxicity, iron, apoptosis