Chinese Journal of Applied Chemistry ›› 2018, Vol. 35 ›› Issue (12): 1478-1484.DOI: 10.11944/j.issn.1000-0518.2018.12.180046

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Investigation on Self-assembly of Nanocontainers by Vesiculation of Conjugated Linoleic Acid and Sodium Alginate and Their Drug Delivery Behavior

FAN Ye,HAN Yichen,XIA Yongmei,BO Chunling,WANG Shuyu,FANG Yun   

  1. Key Laboratory of Synthetic and Biological Colloids(Ministry of Education),School of Chemical and Material Engineering,Jiangnan University,Wuxi,Jiangsu 214122,China
  • Received:2018-02-09 Accepted:2018-06-04 Online:2018-12-05 Published:2018-12-10
  • Contact: XIA Yongmei
  • Supported by:
    Supported by the National Key Research and Development Program of China(No.2017YFB0308705), the National Natural Science Foundation of China(No.21606107, No.21276113), the National Students' Platform for Innovation and Entrepreneurship Training Program of China(No.201710295006)


Fatty acid vesicles(FAVs) are a kind of important nanocontainers, but they are inherently alkaline-adapted and the pH window for the FAV formation is very narrow, which hinders their application in drug delivery. In this work, the vesicular nanocontainers were fabricated by self-assembly of conjugated linoleic acid(CLA) and sodium alginate(SA) in neutral pH range, and the membrane stability of the FAVs was enhanced. Dynamic light scattering(DLS) and transmission electron microscopy(TEM) results indicated that the vesicular nanocontainers with vesicular diameter of 50~250 nm were self-assembled in neutral pH range when the mass fraction of SA was 25%~50%. Moreover, the size of the vesicular nanocontainers increased with the increase of mass fraction of SA at pH=7.4. Based on the chemical species of SA and CLA in neutral pH range, it was proposed that hydrogen bonding is the driving force to self-assemble them into the vesicular nanocontainers. In vitro drug release results showed that the vesicular nanocontainers had a higher encapsulation efficiency and better sustained release effect. The vesicular nanocontainers are expected to be promising carriers in drug delivery.

Key words: nanocontainer, fatty acid vesicle, conjugated linoleic acid, sodium alginate, drug delivery