Chinese Journal of Applied Chemistry ›› 2017, Vol. 34 ›› Issue (10): 1172-1176.DOI: 10.11944/j.issn.1000-0518.2017.10.170124

• Orginal Article • Previous Articles     Next Articles

Synthesis and DNA Cleavage Activity of Pyrazinedimethylformamide Bridged Apigenin Copper(Ⅱ) Complex

HE Daqinga,JIANG Shangfeib,CHEN Yua,WEN Lijuna*(),TANG Yidia,LI Xinyua   

  1. aCollege of Pharmacy
    b Institute of Basic Medicine and Life Science,Hainan Medical College,Haikou 571199,China
  • Received:2017-04-21 Accepted:2017-07-03 Published:2017-09-29 Online:2017-09-29
  • Contact: WEN Lijun
  • Supported by:
    Supported by Natural Science Foundation of Hainan Province(No.20152040), the National Training Project of Innovation and Entrepreneurship for Undergraduate(No.201511810009), the Hainan Medical College's Training Project of Innovation and Entrepreneurship for Undergraduate(No.HYCX2014015)


Pyrazinedimethylformamide bridged apigenin copper(Ⅱ) complex was prepared by solvothermal method with 5,6-dimethyl-2,3-pyrazinedimethylformamide and apigenin as mixed ligands and copper(Ⅱ) acetate. The complex was characterized by ultra-violet and infrared spectroscopies, and thermogravimetric analysis. The DNA cleavage behavior of pyrazinedimethylformamide bridged apigenin copper(Ⅱ) complex has been investigated by agarose gel electrophoresis. The results suggest that the complex can promote the cleavage of pBR322 DNA in the absence of any reducing reagent.

Key words: pyrazinedimethylformamide, apigenin, complex, synthesis, DNA cleavage activity