Synthesis and Antibacterial Activity of 5,6-Dimethyl-2,3-pyrazinedimethylformamide-Cu

doi:10.11944/j.issn.1000-0518.2016.09.150302

Chinese Journal of Applied Chemistry ›› 2016, Vol. 33 ›› Issue (9): 1056-1060.DOI: 10.11944/j.issn.1000-0518.2016.09.150302

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Synthesis and Antibacterial Activity of 5,6-Dimethyl-2,3-pyrazinedimethylformamide-Cu

WEN Lijun^a,WANG Ying^b,LI Haixia^a^*(),LI Juan^a

^aCollege of Pharmacy,Hainan Medical College,Haikou 571199,China
^bTropical and Laboratory Medicine School,Hainan Medical College,Haikou 571199,China

Received:2015-08-19 Accepted:2016-01-05 Published:2016-08-23 Online:2016-08-23
Contact: LI Haixia
Supported by:
Supported by Scientific Research Foundation of Hainan Medical College(No.HY2013-23), Natural Science Foundation of Hainan Province(No.2015040)

Abstract

Abstract:

5,6-Dimethyl-2,3-pyrazinedimethylformamide-Cu was prepared from Cu(CH₃COO)₂ and 5,6-dimethyl-2,3-pyrazinedimethylformamide which was synthesized via hydrolysis of 5,6-dimethyl-2,3-pyrazinecarbonitrile in the dilute basic solution using H₂O₂ as the oxidant. The antibacterial activity of 5,6-dimethyl-2,3- pyrazinedimethylformamide and the complex were compared by the Oxford cup method and tube double dilution method. The complex was characterized by UV and IR spectroscopies and TGA. The 5,6-dimethyl-2,3-pyrazinedimethylformamide-Cu shows good bacteriostatic and bactericidal effects. Both the minimum antimicrobial and the germicidal dosages against E.coli and Staphylococcus aureus are 50 mg/L and 25 mg/L, respectively, while 5,6-dimethyl-2,3-pyrazinedimethylformamide does not show obvious inhibitory effect, providing a reference for the clinical treatment of diseases and the development of food additives.

Key words: dimethyl-pyrazinedimethylformamide, copper complex, synthesis, antibacterial activity

WEN Lijun, WANG Ying, LI Haixia, LI Juan. Synthesis and Antibacterial Activity of 5,6-Dimethyl-2,3-pyrazinedimethylformamide-Cu[J]. Chinese Journal of Applied Chemistry, 2016, 33(9): 1056-1060.

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Synthesis and Antibacterial Activity of 5,6-Dimethyl-2,3-pyrazinedimethylformamide-Cu

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