Synthesis, Crystal Structure, Thermal Stability and DNA Interaction of the Dibutytin Complex Based on Salicylacylhydrazone

doi:10.11944/j.issn.1000-0518.2015.05.140324

Chinese Journal of Applied Chemistry ›› 2015, Vol. 32 ›› Issue (5): 562-569.DOI: 10.11944/j.issn.1000-0518.2015.05.140324

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Synthesis, Crystal Structure, Thermal Stability and DNA Interaction of the Dibutytin Complex Based on Salicylacylhydrazone

ZHENG Jianhua^a, LIU Jun^a, XIAO Yao^a, DAI Linglin^a, LI Haiyang^a, TAN Yuxing^b, FENG Yonglan^a, JIANG Wujiu^a, YU Jiangxi^a, KUANG Daizhi^{a, *}

^aKey Laboratory of Functional Organometallic Materials of College of Hu'nan Province, Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hu'nan 421008, China
^bCollege of Chemistry and Chemical Engineering, Hu'nan Normal University, Changsha 410081, China

Received:2014-09-18 Revised:2014-12-18 Accepted:2015-01-12 Published:2015-05-05 Online:2015-05-05
Contact: KUANG Daizhi
Supported by:
Supported by the National Students' Innovation and Entrepreneurship Training Program(No.201310546127);Students Research Study Project of Hu'nan Province(No.cx1301), the Scientific & Technological Projects of Hu'nan Province of China(No.2013TZ2025, 2014NK3086, 2014FJ3060);Scientific Research Fund of Hu'nan Provincial Education Department of China(No.14C0171)

Abstract

Abstract:

2-(Salicyloylhydrazone)propionic acid dibutytin complex was synthesized via the reaction of 2-(salicyloylhydrazone)propionic acid with dibutyltin oxide. The complex was characterized by IR, ¹H NMR, ¹³C NMR spectroscopy, and elemental analysis. The crystal structure was determined to be a tetragonal system by single crystal X-ray diffraction. The crystal structure of the complex belongs to a centrosymmetric structure mode with a four-member central Sn₂O₂ unit, in which the central Sn atom is seven-coordinated in a distorted pentagonal pyramid configuration. The complex is stable below 103 ℃ according to thermal analysis. The interaction between the complex and Herring sperm DNA was studied by UV spectroscopy, ethidium bromide(EB) fluorescent probe and viscosity, and the results suggest the intercalation interaction between the complex and Herring sperm DNA.

Key words: organotin complex, synthesis, crystal structure, thermal stability, DNA

CLC Number:

ZHENG Jianhua, LIU Jun, XIAO Yao, DAI Linglin, LI Haiyang, TAN Yuxing, FENG Yonglan, JIANG Wujiu, YU Jiangxi, KUANG Daizhi. Synthesis, Crystal Structure, Thermal Stability and DNA Interaction of the Dibutytin Complex Based on Salicylacylhydrazone[J]. Chinese Journal of Applied Chemistry, 2015, 32(5): 562-569.

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Synthesis, Crystal Structure, Thermal Stability and DNA Interaction of the Dibutytin Complex Based on Salicylacylhydrazone

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