Abstract:

A novel Cu(Ⅱ) compound, C₃₂H₄₆CuN₂O₄([CuL]), has been synthesized in ethanol by the reaction of H₂L(H₂L=4, 4', 6, 6'-tetra(tert-butyl)-2, 2'-[ethylenedioxybis(nitrilomethylidyne)]diphenol) with copper(Ⅱ) acetate monohydrate at room temperature and characterized by IR spectroscopy, elemental analyses and X-ray crystallography. The X-ray crystal structure of [CuL] crystallizes in a monoclinic system, space group C2/c, with a=2.7231(3) nm, b=1.1196(3) nm, c=1.0704(2) nm, α=90.00°, β=101.293(2)°, γ=90.00°, V=3.2002(11) nm³, Z=4, M_r=586.25, D_c=1.217 g/cm³, μ=0.718 mm^-1, F(000)=1252, R₁=0.0957, wR₂=0.2297. The symmetric unit in [CuL] contains one Cu(Ⅱ) atom and one coordinated L molecule. The central Cu(Ⅱ) atom are four-coordinated by N1, N1#, O2 and O2# atoms from the coordinated L unit. A slightly distorted tetrahedral geometry is formed around the central Cu(Ⅱ) atom. The antibacterial activities of H₂L and [CuL] are investigated using K-B method, the results indicate that [CuL] has remarkable antibacterial effect on Staphylococcus aureus, Escherichia coli and Withered grass bacillus. [CuL] has stronger activities against the three bacterias than the H₂L ligand.

Key words: Cu(Ⅱ) complex, synthesis, structure, antibacterial activity