Synthesis and Biological Activity of Schiff Bases

doi:10.11944/j.issn.1000-0518.2015.04.140286

Chinese Journal of Applied Chemistry ›› 2015, Vol. 32 ›› Issue (4): 392-398.DOI: 10.11944/j.issn.1000-0518.2015.04.140286

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Synthesis and Biological Activity of Schiff Bases

YANG Fengke^*, HAN Jian, WANG Yongchun, CHEN Fang

College of Chemical Engineering,Qingdao University of Science and Technology,Qingdao,Shangdong 266042,China

Received:2014-08-14 Revised:2014-10-29 Published:2015-04-10 Online:2015-04-10
Contact: Corresponding author:YANG Fengke, professor; Tel:0532-84023030; Fax:0532-84023271; E-mail:1018897098@qq.com; Research interests:organic synthesis
Supported by:
Supported by the Natural Science Foundation of Shandong Province (No.Q2006B02)

Abstract

Abstract:

With raw materials of benzoyl chloride and p-bromophenol, mono-Schiff base, 2-[(2-aminophenylimino)phenylmethyl]-4-bromophenol, is obtained through multi-step reactions of esterification, Fries rearrangement and condensation. The mono-Schiff base reacts with aldehydes and ketones to give five asymmetric di-Schiff bases and two symmetric di-Schiff bases. These Schiff bases, particularly those containing sulfur atom in the molecule, show good antibacterial activities with a minimum inhibitory concentration of 1×10^-4g/L.

Key words: Schiff base, synthesis, rearrangement, antibacterial activity

CLC Number:

O662.4

YANG Fengke, HAN Jian, WANG Yongchun, CHEN Fang. Synthesis and Biological Activity of Schiff Bases[J]. Chinese Journal of Applied Chemistry, 2015, 32(4): 392-398.

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Synthesis and Biological Activity of Schiff Bases

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