Controlled Drug Release Behaviors of Chitosan-Poly(acrylic acid) Composite Hydrogels

doi:10.3724/SP.J.1095.2014.30659

Chinese Journal of Applied Chemistry

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Controlled Drug Release Behaviors of Chitosan-Poly(acrylic acid) Composite Hydrogels

YANG Xiaoci, REN Jie^*, YAO Mengqi, ZHANG Xiaoyan, YANG Wu

(College of Chemistry and Chemical Engineering,Northwest Normal University,Lanzhou 730070,China)

Received:2013-12-24 Revised:2014-02-06 Published:2014-09-04 Online:2014-09-04

Abstract

Abstract: The chitosan(Cs) and acrylic acid(AA) were used to prepare the composite hydrogel(Cs-PAA) by radical polymerization method. The influences of reaction temperature, neutralization degree of acrylic acid, amounts of cross-linking agent and acrylic acid on the swelling degree of the composite hydrogels were investigated. In addition, the controlled release behaviors of prepared hydrogels for niacin were evaluated. The swelling degree of prepared hydrogels is up to 1228 g/g. It exhibits excellent pH and ionic strength sensitivity. The cumulative release rate in a pH=6.86 buffer solution is significantly higher than that in a pH=1.8 buffer solution. Therefore, the hydrogels can be used as carriers of intestinal oral drugs.

Key words: composite hydrogel, swelling degree, drug release, niacin

CLC Number:

O646.9

YANG Xiaoci, REN Jie*, YAO Mengqi, ZHANG Xiaoyan, YANG Wu. Controlled Drug Release Behaviors of Chitosan-Poly(acrylic acid) Composite Hydrogels[J]. Chinese Journal of Applied Chemistry, DOI: 10.3724/SP.J.1095.2014.30659.

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Controlled Drug Release Behaviors of Chitosan-Poly(acrylic acid) Composite Hydrogels

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