Abstract:

The arginase inhibitor N^ω-hydroxy-nor-L-arginine dihydrochloride was successfully synthesized from N^α-Boc-L-glutamine precursor. The expensive reagent was not required in the synthetic process and a seven-step reaction was reduced to a three-step one. Not only was the separation procedure simplified, but also the total yield was increased from 21% to 37%.

Key words: arginase inhibitor, amino-protecting, synthesis