Abstract:

Thirteen new 2-aryloxy-3-phenyl-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-ones were synthesized in 63%~78% yields via the aza-Wittig reaction of (4,5,6-trihydrocyclopentathiophen-2-ylimino)(triphenyl)phosphorane with phenyl iso-cyanate， and subsequent reaction with phenols. Their structures were confirmed by IR， 1H NMR， MS and element analysis. The bacteriostatic activities of the new compounds were tested, indicating that bacteriostatic activities of them against fungus（Penicillium citrinum Thom） are better than those against bacteria.

Key words: thienopyrimidinone, aza-Wittig reaction, synthesis, bacteriostatic activities