Abstract: The chiral recognition action of β-cyclodextrin(CD) to D/L-tyrosine(D/L-tyr) have been studied by circular dichroism measurement. The solid supramolecular inclusion compound of β-CD with L-tyr has been prepared and characterized by elemental analysis, thermal analysis, thin-layer chromatography and X-ray diffraction analysis. The inclusion equilibrium constants were obtained approximately by fluorescence spectrophotometry. The results indicated that β-CD showed a higher affinity for L-tyr than for D-tyr and it formed a 1へ1 hostguest compound with Ltyr of constitution L-tyr/β-CD·12H₂O. The formation constant is calculated to be 5.13×10³ mol^-1L. The inclusion compound had a more or less greater thermal stability than tyrosine and β-CD.

Key words: β-cyclodextrin, D/L-tyrosine, supramolecular inclusion compound, synthesis, chiral recognition