Diastereoselective Synthesis of Asymmetrical 1,3,2-dioxaphosphorins and Their Biological Activity

Chinese Journal of Applied Chemistry ›› 1998, Vol. 0 ›› Issue (2): 109-111.

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Diastereoselective Synthesis of Asymmetrical 1,3,2-dioxaphosphorins and Their Biological Activity

Shao Ruilian, Yang Minhua, Cheng Junran

Research Institute of Elemento Organic Chemistry Nankai University, State Key Laboratory of Elemento Organic Chemistry, Tianjin 300071

Received:1997-06-04 Revised:1997-12-08 Published:1998-04-10 Online:1998-04-10

Abstract

Abstract: Diastereomers of 2-oxo-2-substituted phenoxy-4-phenyl-5,5-dimethyl-1,3,2-dioxaphosphorin were synthesized. The synthetic methods, solvents and salts appeared to exhibit significant influences on the cis/trans ratio of the products. The isomerization between cis and trans cyclic phosphates was investigated. The preliminary bioassay indicated that some isomers have herbicidal and plant growth activity.

Key words: dioxaphosphorin, stereoselective synthesis, diastereomer, biological activity

Shao Ruilian, Yang Minhua, Cheng Junran. Diastereoselective Synthesis of Asymmetrical 1,3,2-dioxaphosphorins and Their Biological Activity[J]. Chinese Journal of Applied Chemistry, 1998, 0(2): 109-111.

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Diastereoselective Synthesis of Asymmetrical 1,3,2-dioxaphosphorins and Their Biological Activity

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