Synthesis and Biological Activity Study of Ionic Organotin Compounds

doi:10.3724/SP.J.1095.2011.00347

Chinese Journal of Applied Chemistry ›› 2011, Vol. 28 ›› Issue (04): 387-393.DOI: 10.3724/SP.J.1095.2011.00347

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Synthesis and Biological Activity Study of Ionic Organotin Compounds

ZHONG Guiyun^2*, SUN Lijuan¹

(1.Institute of Elemento-Organic Chemistry,Nankai University,Tianjin 300071;
2.Department of Matiarals Technology,Jiangmen Polytechnic,Jiangmen 529090)

Received:2010-06-17 Revised:2010-09-21 Published:2011-04-10 Online:2011-04-10

Abstract

Abstract:

A series of ionic organotin(IV) complexes with general formula [HNR3][(PhCH2)3Sn(μ2-SCH2COO)Cl], [HNR3][(Ph3Sn)3(O2CCH2CO2)2]·CH3CH2OH and [HNR3][MeCy2ClSnO2CCH2CO2SnClCy2Me] were synthesized by the reaction of organic acid with organotin halide in the presence of an organic base. The results of the anti-tumor, bactericidal and acaricidal activity show that some complexes have good biological activity. The inhibition rate of [HNR3][(Ph3Sn)3(O2CCH2CO2)2]·CH3CH2OH and [HNR3][MeCy2ClSnO2CCH2CO2SnClCy2Me] complexes for A-549, HCT-8 and Bel-7402 was about 90%, the mortality rate of [HNR3][MeCy2ClSnO2CCH2CO2SnClCy2Me] complexes for Gibberella zeae, Alternaria solani, Phomopsis asparagi, Physalospora piricola, Cercospora arachidicol was 100%, the mortality rate of [HNR3][MeCy2ClSnO2CCH2CO2SnClCy2Me] complexes for acaricidal activity was more than 90%.

Key words: ionic organotin, Biological Activity, Anti-tumor Activity, Sterilization Activity, Acaricidal activity

CLC Number:

O621.3

ZHONG Guiyun2*, SUN Lijuan1. Synthesis and Biological Activity Study of Ionic Organotin Compounds[J]. Chinese Journal of Applied Chemistry, 2011, 28(04): 387-393.

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Synthesis and Biological Activity Study of Ionic Organotin Compounds

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