Study of in vitro Drug Release from Chitosan Composite Membranes Containing Antibiotic Drugs

Chinese Journal of Applied Chemistry ›› 1997, Vol. 0 ›› Issue (5): 67-70.

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Study of in vitro Drug Release from Chitosan Composite Membranes Containing Antibiotic Drugs

Fang Yue'e¹, L? Xiaobin¹, Wang Yongming¹, Zhou Tao¹, Feng Jianping¹, Chen Bojun², Li Lisheng², Wang Yongjie², Wang Shaogen²

1. Department of Applied Chemistry, University of Science andTechnology of China, Hefei 230026;
2. First Affiliated Hospital of Anhui Medical University, Hefei

Received:1996-12-31 Revised:1997-07-10 Published:1997-10-10 Online:1997-10-10

Abstract

Abstract: A novel composite membrane based on chitosan/starch/polyvinyl alcohol was prepared by solvent casting technique and its mechanical properties were measured. The drug release and its mechanism in static state from the composite membranes containing ciprofloxacin and protocatechuic acid have been investigated. The release rate was found to be controlled by the starch content in membrane matrices as well as by crosslinking state.

Key words: chitosan composite membrane, protocatechuic acid, ciprofloxacin, drug release

Fang Yue'e, L? Xiaobin, Wang Yongming, Zhou Tao, Feng Jianping, Chen Bojun, Li Lisheng, Wang Yongjie, Wang Shaogen. Study of in vitro Drug Release from Chitosan Composite Membranes Containing Antibiotic Drugs[J]. Chinese Journal of Applied Chemistry, 1997, 0(5): 67-70.

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Study of in vitro Drug Release from Chitosan Composite Membranes Containing Antibiotic Drugs

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