Study on the Niclosamide Transdermal Therapeutic System

Chinese Journal of Applied Chemistry ›› 1997, Vol. 0 ›› Issue (4): 25-28.

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Study on the Niclosamide Transdermal Therapeutic System

Qi Guorong¹, Yang Yunsong¹, Yang Shilin ¹, Zhang Guolin², Zhang Qingdi²

1. Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027;
2. Department of Pharmacy, Zhejiang Medical University, Hangzhou

Received:1996-10-20 Revised:1997-05-26 Published:1997-08-10 Online:1997-08-10

Abstract

Abstract: The efficiency of penetration enhancers for niclosamide has been studied using double cell skin permeation system. It was found that oleic acid was a good enhancer for niclosamide and was more efficient than azone. Azone showed a synergism with oleic acid or propylene glycol. It was also demonstrated that niclosamide could be used as a long-lasting liniment. The mechanism of the effect of azone and oleic acid has been investigated by IR and DSC techniques.

Key words: niclosamide, transdermal therapeutic system, azone, oleic acid

Qi Guorong, Yang Yunsong, Yang Shilin , Zhang Guolin, Zhang Qingdi. Study on the Niclosamide Transdermal Therapeutic System[J]. Chinese Journal of Applied Chemistry, 1997, 0(4): 25-28.

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Study on the Niclosamide Transdermal Therapeutic System

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