Chinese Journal of Applied Chemistry ›› 1997, Vol. 0 ›› Issue (3): 107-108.

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Studies on Synthesis of Nitriloalkylenephosphonic Acids(Ⅳ): Synthesis of N-Alkyl-α-Aminobenzylenephosphonic Acids in Tetramethylenesulfone

Zhu Chuanfang, Xiao Haiyan, Li Zhonghua   

  1. Department of Chemistry, Huazhong Normal University, Wuhan 430070
  • Received:1996-08-09 Revised:1997-02-03 Published:1997-06-10 Online:1997-06-10

Abstract: Some N-alkyl-α-aminobenzylenephosphonic acids were prepared directly from benzaldehyde or p-nitrobenzaldehyde with amines and phosphorous acid using tetramethylenesulfone as solvent. The method offers the advantages of giving good yields, easy purification of the products, simplicity and rapidity.

Key words: N-alkyl-α-aminobenzylenephosphonic acid, tetramethylenesulfone, synthesis