Synthesis and Characterizaion of Mimic Tripeptides with GPX Activity

Chinese Journal of Applied Chemistry ›› 1994, Vol. 0 ›› Issue (6): 77-80.

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Synthesis and Characterizaion of Mimic Tripeptides with GPX Activity

Zhu Zhenqi¹, Sun Qi'an¹, Ding Lan¹, Luo Guimin¹, Li Wei²¹, Shen Jiacong³

1. The State Key Laboratory of Enzyme Engineering, Jilin University, Changchun 130023;
2. Department of Molecnlar Biology, Jilin University, Changchun;
3. Department of Chemistry, Jilin University, Changchun

Received:1994-03-21 Revised:1994-07-12 Published:1994-12-10 Online:1994-12-10

Abstract

Abstract: The alpha-amino and alpha-carboxyl group in glutamic acid (Glu) were protected by specific coprotection method,γ-Glu-Ser-Gly was synthesized by the liquid peptide method. The prepared mimic tripeptides were used for the chemical mutation of PMSF and H₂Se, as well as γ-Glu-SeCys-Gly, The structures of mimic tripeptides were determined by elemental analysis and amino acid analysis. The valency and quantity of Se in mimic tripeptides were determined.

Key words: mimic tripeptide, GPX, synthesis, characterization

Zhu Zhenqi, Sun Qi'an, Ding Lan, Luo Guimin, Li Wei, Shen Jiacong. Synthesis and Characterizaion of Mimic Tripeptides with GPX Activity[J]. Chinese Journal of Applied Chemistry, 1994, 0(6): 77-80.

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Synthesis and Characterizaion of Mimic Tripeptides with GPX Activity

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