SYNTHESES AND EFFECTS OF AMIDE DERIVATIVES OF β-CARBOXYETHYLGERMANIUM SESQUIOXIDES SOME AMINO ACIDS AND HETROCYCLIC AMINES ON THE HUMAN CANCER AND DIPLOID CELLS IN VITRO

Chinese Journal of Applied Chemistry ›› 1993, Vol. 0 ›› Issue (6): 83-85.

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SYNTHESES AND EFFECTS OF AMIDE DERIVATIVES OF β-CARBOXYETHYLGERMANIUM SESQUIOXIDES SOME AMINO ACIDS AND HETROCYCLIC AMINES ON THE HUMAN CANCER AND DIPLOID CELLS IN VITRO

Zhang Shugong¹, Lu Chuanxin¹, Cai Jiwen¹, Ni Jiazuan¹, Nie Yuxiu², Chen Yulan²

1. Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 130022 Changchun;
2. Norman Bethune University of Medicine Sciences, Changchun

Received:1993-02-08 Revised:1993-06-12 Published:1993-12-10 Online:1993-12-10

Abstract

Abstract: Eight amide derivatives of β-carboxyethylgermanium sesquioxides of ethyl glycihate,ethyl phenylalaninate,piperidine, 2-amino-benzothiazole and 4-aminopyridine were prepared by two defferent methods and characterized by elemental analysis, IR and ¹H NMR spectra. The influence of three of these compounds on human cancer and diploid cells were observed in vitro.

Key words: organogermanium, amino acid amide, hetrocyclic amide, synthesis, anticancer

Zhang Shugong, Lu Chuanxin, Cai Jiwen, Ni Jiazuan, Nie Yuxiu, Chen Yulan. SYNTHESES AND EFFECTS OF AMIDE DERIVATIVES OF β-CARBOXYETHYLGERMANIUM SESQUIOXIDES SOME AMINO ACIDS AND HETROCYCLIC AMINES ON THE HUMAN CANCER AND DIPLOID CELLS IN VITRO[J]. Chinese Journal of Applied Chemistry, 1993, 0(6): 83-85.

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SYNTHESES AND EFFECTS OF AMIDE DERIVATIVES OF β-CARBOXYETHYLGERMANIUM SESQUIOXIDES SOME AMINO ACIDS AND HETROCYCLIC AMINES ON THE HUMAN CANCER AND DIPLOID CELLS IN VITRO

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