SYNTHESIS,CHARACTERIZATION AND ANTITUMOR ACTIVITY OF COMPLEXES OF 2-CARBONYLPROPIONYL (PYRIDINE-4-FORMYL) HYDRAZONE WITH RARE EARTHS

Chinese Journal of Applied Chemistry ›› 1992, Vol. 0 ›› Issue (3): 31-36.

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SYNTHESIS,CHARACTERIZATION AND ANTITUMOR ACTIVITY OF COMPLEXES OF 2-CARBONYLPROPIONYL (PYRIDINE-4-FORMYL) HYDRAZONE WITH RARE EARTHS

Yang Zhengyin, Wang Liufang, Wu Jigui, Li Xingyu

Department of Chemistry, Lanzhou University, Lanzhou 73000

Received:1991-03-09 Revised:1991-08-20 Published:1992-06-10 Online:1992-06-10

Abstract

Abstract: 2-Carbonylpropionyl (pyridine-4-formyl) hydrazone (H₂PPPH)has been synthesized by a simple method. It is a weak acid, and the complexation was carried out in the water solution of rare earth carbonates. 13 complexes have general composition of RE₂(PPFH)₃·nH₂O (RE=La～Yb, n=2～3). The structures and properties of the complexes were characterized by elemental analysis, IR, UV spectra, TGA-DTA, molar conductance and ¹H NMR measuramcnts. Eu₂(PPFH)₃·3H₂O was showed to have a certain antitumor activity.

Key words: 2-carbonylpropionic acid, isonicotinyl hydrazine, hydrazone, rare earth, complex, antitumor activity, synthesis

Yang Zhengyin, Wang Liufang, Wu Jigui, Li Xingyu. SYNTHESIS,CHARACTERIZATION AND ANTITUMOR ACTIVITY OF COMPLEXES OF 2-CARBONYLPROPIONYL (PYRIDINE-4-FORMYL) HYDRAZONE WITH RARE EARTHS[J]. Chinese Journal of Applied Chemistry, 1992, 0(3): 31-36.

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SYNTHESIS,CHARACTERIZATION AND ANTITUMOR ACTIVITY OF COMPLEXES OF 2-CARBONYLPROPIONYL (PYRIDINE-4-FORMYL) HYDRAZONE WITH RARE EARTHS

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