Abstract: The reaction kinetics of CDDP (cisplatin), CEDCA (carboplatin) with guanosine and L-Met are compared by means of HPLC.The results show that the reaction rate of CDDP with Guo is greater than that with CBDCA. However, CBDCA gave more 1:2 products with Guo than 1:1 products and its second hydrolysis rate constant k₂ is much greater than its first one k₁.For reactions of CDDP and CBDCA with L-Met the second rate constants are measured as 36.1?10^-3 and 5.0?10^-3M^-1S^-1, respectively. This may be one of the reasons that CBDCA shows less nephrotoxicity than CBDP.

Key words: cisplatin(CDDP), carboplatin(CBDCA), guanosine, L-Met, HPLC