One-pot Synthesis of Aroyl Cyanides Under Solvent-free and Catalyst-free Conditions

doi:10.3724/SP.J.1095.2014.30524

Chinese Journal of Applied Chemistry

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One-pot Synthesis of Aroyl Cyanides Under Solvent-free and Catalyst-free Conditions

ZHAO Zhouxing

(College of Chemical Engineering,Qinghai University,Xining 810016,China)

Received:2013-10-24 Revised:2014-02-22 Published:2014-08-10 Online:2014-08-10
About author:ZHAO Zhouxing, professor; Tel:0971-3975571; E-mail：zhao_zx05@163.com;Research interests: fine organic synthesis

Abstract

Abstract: A series of aroyl cyanides was synthesized by nucleophilic substitution reactions of aromatic acids with thionyl chloride and potassium ferricyanide in one-pot under solvent-free and catalyst-free conditions. The effects of the reaction temperature and time on the yield of the products were investigated. The yields of aroyl cyanides were up to 71%~92% when the reactions were performed at 180 ℃ for 2 h. The structures of the products were confirmed by IR, 1H NMR and 13C NMR spectroscopy. This method has advantages of simple work-up procedure, high yield, and eco-friendly solvent-free and catalyst-free conditions.

Key words: one-pot, solvent-free, aromatic acyl chloride, aroyl cyanides, synthesis

CLC Number:

O623.5

ZHAO Zhouxing. One-pot Synthesis of Aroyl Cyanides Under Solvent-free and Catalyst-free Conditions[J]. Chinese Journal of Applied Chemistry, DOI: 10.3724/SP.J.1095.2014.30524.

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One-pot Synthesis of Aroyl Cyanides Under Solvent-free and Catalyst-free Conditions

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