Synthesis，Characterization and Antitumor Activitiesof of Cu(Ⅱ)-Aspirin Complex

doi:10.3724/SP.J.1095.2014.30202

Chinese Journal of Applied Chemistry

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Synthesis，Characterization and Antitumor Activitiesof of Cu(Ⅱ)-Aspirin Complex

LIU Tao¹, WEI Dong¹, JIANG Bo¹, XU Guoyong¹, ZHOU Shuangsheng^1,2*

(1.Department of Pharmacy,Anhui College of Traditional Chinese Medicine，Hefei 230031,China;
2.Center of Modern Experimental Technology,Anhui University,Hefei 230039,China)

Received:2013-04-24 Revised:2013-07-15 Published:2014-03-10 Online:2014-03-10
Supported by:
Supported by the National Natural Science Foundation（21071001） and The Natural Science Foundation Of Anhui Province（1208085MH273）

Abstract

Abstract: A Cu(Ⅱ)-aspirin complex has been synthesized and characterized by IR spectroscopy and single crystal X-ray diffraction analyses. The complex crystallizes in monoclinic space group P21/n with cell parameters of a=8.211(5) nm， b=10.419(5) nm， c=21.003(5) nm， β=98.021(5)°， V=1779.2(14) nm3， Z=4. The interactions of the complex with ct-DNA were studied by UV, fluorescence spectroscopy and cyclic voltammetry method. At the same time, the antitumor activities of the complex against MCF-7 and MGC-803 cell lines were tested by MTT assay. The in vitro inhibitory ratios against two tumor cell lines are 80.01% and 70.16% at concentration of 120 μmol/L, respectively.

Key words: Cu(Ⅱ)-aspirin complex, crystal structure, antitumor activity, ct-DNA, interaction

CLC Number:

O614.1

LIU Tao1, WEI Dong1, JIANG Bo1, XU Guoyong1, ZHOU Shuangsheng1,2*. Synthesis，Characterization and Antitumor Activitiesof of Cu(Ⅱ)-Aspirin Complex[J]. Chinese Journal of Applied Chemistry, DOI: 10.3724/SP.J.1095.2014.30202.

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Synthesis，Characterization and Antitumor Activitiesof of Cu(Ⅱ)-Aspirin Complex

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