Determination of Acetaminophen in Pharmaceuticals by Luminol-H2O2-Silver Nanoparticle Chemiluminescence System

doi:10.3724/SP.J.1095.2013.30065

Chinese Journal of Applied Chemistry

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Determination of Acetaminophen in Pharmaceuticals by Luminol-H2O2-Silver Nanoparticle Chemiluminescence System

FAN Xuemei^1,2*, WANG Shumin¹, CUI Xiaowei¹

(1.Department of Chemistry and Chemical Engineering,Shuoluo College,Shangluo 726000,China;
2.Shangluo Engineering of Materials Science and Research Institute,Shangluo 726000,China)

Received:2013-01-25 Revised:2013-04-03 Published:2014-01-10 Online:2014-01-10

Abstract

Abstract: A novel method for the determination of acetaminophen was developed based on its inhibition effect on the luminol-H2O2-silver nanoparticle chemiluminescence system. Various factors influencing the chemiluminescence system were investigated and the possible mechanism was also studied. Under the optimum conditions, the linear range for the determination of acetaminophen is 2.0×10-8 to 1.0×10-4 mol/L with a detection limit of 4.0×10-9 mol/L. The relative standard deviation is 2.6% for 1.0× 10-7 mol/L acetaminophen solution in nine repeated measurements. The method was successfully applied to the determination of acetaminophen in pharmaceutical.

Key words: chemiluminescence, Ag nanoparticles, luminol, acetaminophen

CLC Number:

O657.2

FAN Xuemei1,2*, WANG Shumin1, CUI Xiaowei1. Determination of Acetaminophen in Pharmaceuticals by Luminol-H2O2-Silver Nanoparticle Chemiluminescence System[J]. Chinese Journal of Applied Chemistry, DOI: 10.3724/SP.J.1095.2013.30065.

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Determination of Acetaminophen in Pharmaceuticals by Luminol-H2O2-Silver Nanoparticle Chemiluminescence System

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