Synthesis of Amphiphilic β-Cyclodextrins and Their Nanospheres in Water

doi:10.3724/SP.J.1095.2012.20164

Chinese Journal of Applied Chemistry

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Synthesis of Amphiphilic β-Cyclodextrins and Their Nanospheres in Water

GUO Wenyan^1,2, ZHAO Minggang^1*, HAO Aiyou³

(1.School of Chemistry and Materials Science,Shanxi Normal University,Linfen 041004,China;
2.Modern College of Arts and Science of Shanxi Normal University,Linfen 041000,China;
3.School of Chemistry and Chemical Engineering,Shandong University,Ji′nan 250100,China)

Received:2012-04-19 Revised:2012-06-12 Published:2013-03-10 Online:2013-03-10

Abstract

Abstract: Four amphiphilic bifunctionalized β-cyclodextrin derivatives with low degree of substitution(DS) were conveniently synthesized via the reaction of 2-O-(2-hydroxypropyl)-β-cyclodextrin with Lauryl glycidol ether, tetradecyl glycidol ether, hexadecyl glycidol ether and octadecyl glycidol ether in pyridine, respectively. The four amphiphilic β-CD derivatives(DS 1.87, 1.95, 2.14 and 1.80, respectively) could self-assemble in water to form stable nanospheres with improved dispersion degree and uniformity up to 2~3 weeks.

Key words: amphiphilic, O-(hydroxypropyl)-&, beta, -cyclodextrin, glycidol ether, nanospheres

CLC Number:

O624.3

GUO Wenyan1,2, ZHAO Minggang1*, HAO Aiyou3. Synthesis of Amphiphilic β-Cyclodextrins and Their Nanospheres in Water[J]. Chinese Journal of Applied Chemistry, DOI: 10.3724/SP.J.1095.2012.20164.

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Synthesis of Amphiphilic β-Cyclodextrins and Their Nanospheres in Water

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