Abstract: Four porphyrin-5-fluorouracil conjugates, i.e. 5-[3-(2-(5-fluorouracil-1-yl)-ethoxy)phenyl]-10,15,20-tri(3-chlorophenyl)porphyrin(1a), 5-[3-(2-(5-fluorouracil-1-yl)-ethoxy)phenyl]-10,15,20-tri(3-chlorophenyl)Mn-porphyrin(2a), 5-[3-(3-(5-fluorouracil-1-yl)-propoxy)phenyl]-10,15,20-tri(3-chlorophenyl)Mn-porphyrin(2b) and 5-[3-(4-(5-fluorouracil-1-yl)-butoxy)phenyl]-10,15,20-tri(3-chlorophenyl)Mn-porphyrin(2c), were successfully synthesized and characterized by UV-Vis, IR, MS and elemental analysis. Inhibition activity of the synthesized compounds(2a, 2b and 2c) to human gastric cancer cell line BGC-823 was tested using the methyl thiazolyl tetrazolium(MTT) method. The IC50 value of 2b was 1.34 μmol/L, indicating that compound 2b had certain cytotoxic effect.

Key words: manganoporphyrin, fluorouracil, synthesis, human gastric cancer cell line BGC-823