Synthesis and Anti-tumor activity of N-(Substituted Benzyl) -3,5-bis(Benzylidene)-4-piperidones

doi:10.3724/SP.J.1095.2012.00126

Chinese Journal of Applied Chemistry

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Synthesis and Anti-tumor activity of N-(Substituted Benzyl) -3,5-bis(Benzylidene)-4-piperidones

SHAN Zhenguo, XUE Sijia^*

(Department of Chemistry,College of Life and Environmental Science,Shanghai Normal University,Shanghai 200234)

Received:2011-03-28 Revised:2011-06-13 Published:2012-02-10 Online:2012-02-10

Abstract

Abstract: A series of novel N-(substituted benzyl)-3,5-bis(benzylidene)-4-piperidones(8a~8j) were synthesized uisng substituted benzylamines as precursors via a series of Michael addition, Dieckmann condensation, hydrolysis decarboxylation and Aldol condensation. The structures were confirmed by 1H NMR, IR, MS and elemental analysis. The preliminary biological activity tests by MTT assay indicated that some of the target compounds had good antiproliferative activities against K562, MDR-MB-231 and HO8910PM cells, and therefore showed potential anti-tumors bioactivity.

Key words: N-substituted-piperidone, synthesis, antitumor, MTT

CLC Number:

O622.6

SHAN Zhenguo, XUE Sijia*. Synthesis and Anti-tumor activity of N-(Substituted Benzyl) -3,5-bis(Benzylidene)-4-piperidones[J]. Chinese Journal of Applied Chemistry, DOI: 10.3724/SP.J.1095.2012.00126.

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Synthesis and Anti-tumor activity of N-(Substituted Benzyl) -3,5-bis(Benzylidene)-4-piperidones

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