Chinese Journal of Applied Chemistry ›› 2010, Vol. 27 ›› Issue (03): 304-307.DOI: 10.3724/SP.J.1095.2010.90271

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Selective Synthesis of 2-Benzyl-4-chlorophenol Catalyzed by Zn(OTf)2

MA Zhong-Hua1,2, ZHANG Jia-Yan1, NIE Jin1*   

  1. (1.School of Chemistry and Chemical Engineering,Huazhong University of Science and Technology,Wuhan 430074;
    2.Department of Chemistry,College of Basic Sciences,Huazhong Agricultural University,Wuhan)
  • Received:2009-04-14 Revised:2009-07-23 Published:2010-03-10 Online:2010-03-10

Abstract:

C-Benzylation of 4-chlorophenol(BCP) was selectively perpared via the catalysis of Zn(OTf)2 under mild conditions with an excellent yield. The optimum reaction conditions included that the molar ratio of the reactants (4-chlorophol∶benzyl chloride) was 1.2∶1, 5% Zn(OTf)2(molar ratio), and 6 h  agitation at 60 ℃ in nitromethane. The conversion of 4-chlorophenol and selectivity of BCP were >99% and 94%, respectively under the conditions.

Key words: zinc(Ⅱ) trifluoromethnesulfonate,benzyl-chlorophenol,Friedel-Crafts alkylation,p-chlorophenol,benzyl chloride

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