Synthesis of γ- Aminobutyric Acid Isothiocyanate Conjugated Norcantharidin and Substituted Anilin And Anticonvulsant Activity

doi:10.3724/SP.J.1095.2010.90243

Chinese Journal of Applied Chemistry ›› 2010, Vol. 27 ›› Issue (03): 300-303.DOI: 10.3724/SP.J.1095.2010.90243

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Synthesis of γ- Aminobutyric Acid Isothiocyanate Conjugated Norcantharidin and Substituted Anilin And Anticonvulsant Activity

WEI Chu-Quan, LI Yong-Xiu, SUN Xiao-Fei*

(School of Pharmacy,Medical College of Soochow University,Suzhou 215123)

Received:2009-04-07 Revised:2009-07-15 Published:2010-03-10 Online:2010-03-10

Abstract

Abstract:

In order to find new anticonvulsant compounds, we designed and synthesized eleven target compounds of the γ- Aminobutyric acid isothiocyanate conjugated norcantharidin and substituted anilin. The structures are identified by IR, 1H NMR and HR-MS. Preliminary test of anticonvulsant activity showed that compounds II2, II3 and II8 had appreciable antiepileptic activity.

Key words: norcantharidin, γ- aminobutyric acid isothiocyanate conjugated norcantharidin and substituted anilin, anticonvulsant, synthesis

CLC Number:

O622.7
R914

WEI Chu-Quan, LI Yong-Xiu, SUN Xiao-Fei*. Synthesis of γ- Aminobutyric Acid Isothiocyanate Conjugated Norcantharidin and Substituted Anilin And Anticonvulsant Activity[J]. Chinese Journal of Applied Chemistry, 2010, 27(03): 300-303.

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Synthesis of γ- Aminobutyric Acid Isothiocyanate Conjugated Norcantharidin and Substituted Anilin And Anticonvulsant Activity

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