Enantiomeric separation of 1-dimethyl-3-phenylpropylamine by Pressurized Capillary electrochromatography

doi:10.3724/SP.J.1095.2010.90063

Chinese Journal of Applied Chemistry ›› 2010, Vol. 27 ›› Issue (02): 246-248.DOI: 10.3724/SP.J.1095.2010.90063

• Original Articles • Previous Articles

Enantiomeric separation of 1-dimethyl-3-phenylpropylamine by Pressurized Capillary electrochromatography

LI Ying-Jie*, SUN Feng, GAO Li-Di

(Qiqihar University of Chemistry,Chemical Engineering Institute,Qiqihar 161006)

Received:2009-01-20 Revised:2009-04-02 Published:2010-02-10 Online:2010-02-10

Abstract

Abstract:

1-Dimethyl-3-phenylpropylamine enantiomer was separated with hydroxypropyl-β-cyclodextrin（HP-β-CD） as chiral selector by means of pressurized capillary electrochromatography(pCEC). The optimal experimental conditions are HP-β-CD concentration 10 g/L, background buffer pH=7.6, capillary temperature 16 ℃, voltage 10 kV, and the mobile phase consisted of a solution of acetonitrile and phosphate at a volume ratio of V(CH3CN)∶V(NaH2PO4-Na2HPO4)=60∶40. The method is simple, rapid and the reproducibility is good.

Key words: pressurized capillary electrochromatography(pCEC),dimethylphenylpropylamine,enantiomer separation,hydroxypropyl-β-cyclodextrin

CLC Number:

O657

LI Ying-Jie*, SUN Feng, GAO Li-Di. Enantiomeric separation of 1-dimethyl-3-phenylpropylamine by Pressurized Capillary electrochromatography[J]. Chinese Journal of Applied Chemistry, 2010, 27(02): 246-248.

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Enantiomeric separation of 1-dimethyl-3-phenylpropylamine by Pressurized Capillary electrochromatography

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