Chinese Journal of Applied Chemistry ›› 2024, Vol. 41 ›› Issue (4): 459-471.DOI: 10.19894/j.issn.1000-0518.230251

• Review •    

Advances in Surface-Enhanced Raman Spectroscopy for the Detection of Veterinary Drug Residues in Foods of Animal Origin

Jia-Huan PEI1, Xiao-Hua QI2, Ming-Qiang ZOU2, Yong JIN2, De-Ying WANG1, Yun-Jing LUO1()   

  1. 1.Faculty of Environment and Life,Beijing University of Technology,Beijing 100124,China
    2.Chinese Academy of Inspection and Quarantine,Beijing 116023,China
  • Received:2023-08-22 Accepted:2024-02-01 Published:2024-04-01 Online:2024-04-28
  • Contact: Yun-Jing LUO
  • About
  • Supported by:
    the National Key Research and Development Program(2022YFF0607903);the Basic Research Operating Costs of the Academy of Inspection and Quarantine(2022JK18);the Key Research and Development Program of Hainan Province(SQ2021SHFZ0721)


The safety issue of animal food has received widespread public attention due to increased reports of problematic foods. Once veterinary drugs are overused or abused in the process of animal husbandry, drug residues will bring serious harm to human health. Common residue detection methods have the disadvantages of high cost, slow speed and low efficiency, which usually requires professional personnel to operate, and the traditional physical and chemical methods can't meet the needs of food quality testing. As a result, the research and development of rapid and efficient detection methods for veterinary drug residues is necessary. In recent years, surface-enhanced Raman spectroscopy (SERS) has been widely used in many fields such as authenticity identification, illegal additives detection, agricultural and veterinary residues, etc, and has a broader development prospect in the field of food testing due to its advantages of fast detection and non-destructive. SERS is different from other detection methods in that it can rapidly identify target analytes through signal amplification and highly sensitive fingerprint spectroscopy for qualitative or semi-quantitative analysis. This paper mainly introduces the research and application of Raman spectroscopy and SERS in the detection of veterinary drug residues in foods of animal origin, focusing on the advantages of SERS, the pre-treatment of food samples, and the related research on the detection of a variety of veterinary drugs by SERS combined with other techniques, and proposing the challenges faced by SERS in practical monitoring.

Key words: Food safety, Surface-enhanced Raman spectroscopy, Food of animal origin, Veterinary drug residues, Sample pre-treatment

CLC Number: