Structure and Performance Modulation of Self‑Adhesive SIS/C5 Electrospun Membranes for Transdermal Drug Delivery

doi:10.19894/j.issn.1000-0518.210553

Chinese Journal of Applied Chemistry ›› 2022, Vol. 39 ›› Issue (10): 1523-1532.DOI: 10.19894/j.issn.1000-0518.210553

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Structure and Performance Modulation of Self‑Adhesive SIS/C5 Electrospun Membranes for Transdermal Drug Delivery

Feng-Shuo LIU¹, Qian DONG², Zhong-Fu ZHAO¹(), Wei LIU¹, Chun-Qing ZHANG¹()

^1.State Key Laboratory of Fine Chemicals，School of Chemical Engineering，Dalian University of Technology，Dalian 116024，China
^2.Affiliated Cancer Hospital of Dalian University of Technology （Liaoning Cancer Hospital），Shenyang 110042，China

Received:2021-12-02 Accepted:2022-04-27 Published:2022-10-01 Online:2022-10-05
Contact: Zhong-Fu ZHAO,Chun-Qing ZHANG
About author:zhangchq@dlut.edu.cn
zfzhao@dlut.edu.cn；
Supported by:
the Fundamental Research Funds for the Central Universities(DTU21YG132);the National Natural Science Foundation of China(51673034)

Abstract

Abstract:

Electrospun membranes are widely utilized to enhance the water vapor permeability and drug delivery performance of transdermal drug delivery patches. Due to the lack of adhesion property， however， most of them cannot closely contact with skin， which impedes the delivery of drugs to the skin， thus affecting the transdermal administration. C5 resin is used to endow poly（styrene isoprene styrene）（SIS） electrospun membranes with pressure-sensitive adhesion property. Investigation is performed on how to control the structure， adhesion properties and drug delivery performance of SIS/C5 electrospun membranes loaded with synthetic capsaicin via compositions， drugs and electrospinning conditions. The results demonstrate that the electrospun membrane with a SIS/C5 ratio of 2∶1 has excellent water vapor permeability （7.17×10^－3 g/（h·cm²） and adhesion properties （180（°） peel strength is 0.2 kN/m， tack force is 0.64 N/cm²， holding power is greater than 7 days）. The synthetic capsaicin has good compatibility with the SIS/C5 electrospun membranes， in which no drug crystallizes and the drug loading is beneficial to improve the water vapor permeability. As the drug loading is 8%， the tack force is 0.6～0.8 N/cm²， the 180（°） peel strength is 0.2～0.3 kN/m， the holding power is greater than 7 days， and no residue is left during peeling tests. In vitro drug release indicates that the drug has a behavior of sustained release with a 24-hour cumulative release rate of greater than 50% for all SIS/C5 electrospun membranes， meeting the requirements of transdermal drug delivery patches.

Key words: External patch, Electrospinning, Self-adhesiveness, Drug sustained release

CLC Number:

O613

Feng-Shuo LIU, Qian DONG, Zhong-Fu ZHAO, Wei LIU, Chun-Qing ZHANG. Structure and Performance Modulation of Self‑Adhesive SIS/C5 Electrospun Membranes for Transdermal Drug Delivery[J]. Chinese Journal of Applied Chemistry, 2022, 39(10): 1523-1532.

Figures/Tables 8

Fig.1 SEM images of （A） SC（4∶1）-4%，（B） SC（3∶1）-4%，（C） SC（7∶3）-4%，（D） SC（2∶1）-4%，（E） SC（3∶2）-4% and （F） SC（1∶1）-4%

Table 1 Adhesion performance of fiber membrane matrix with different C5 contents

样品 Sample	初黏力 Tack force/（N·cm^-2）	180（°）剥离强度 180（°） peel strength/（kN·m^-1）	持粘性能 Holding power/d	剥离残留 Stripping residue
SC（4∶1）?4%	0.13±0.01	0.03±0.01	>7	No
SC（3∶1）?4%	0.29±0.02	0.10±0.01	>7	No
SC（7∶3）?4%	0.52±0.03	0.15±0.02	>7	No
SC（2∶1）?4%	0.64±0.02	0.20±0.01	>7	No
SC（3∶2）?4%	0.93±0.03	0.37±0.03	>7	No
SC（1∶1）?4%	1.15±0.04	0.62±0.03	>7	No

Fig.2 WVP of electrospun membranes with different mass ratios of SIS/C5

Fig.3 （A） FT-IR spectra and （B） DSC curves of synthetic capsaicin and drug-loaded membranes

Fig.4 SEM images of （A） SC（2∶1），（B） SC（2∶1）-2%，（C） SC（2∶1）-4%，（D） SC（2∶1）-6% and （E） SC（2∶1）-8%

Fig.5 WVP of electrospun membranes with different synthetic capsaicin contents

Table 2 Adhesion performances of various electrospun membranes with different drug contents

样品 Sample	初黏力 Tack force/（N·cm^-2）	剥离强度 180（°） peel strength/（kN·m^-1）	持粘性能 Holding power/d	剥离残留 Stripping residue
SC（2∶1）	0.77±0.02	0.32±0.01	>7	No
SC（2∶1）?2%	0.72±0.01	0.29±0.01	>7	No
SC（2∶1）?4%	0.64±0.02	0.20±0.01	>7	No
SC（2∶1）?6%	0.67±0.01	0.25±0.03	>7	No
SC（2∶1）?8%	0.68±0.02	0.27±0.01	>7	No

Fig.6 （A） Cumulative release curves and （B） cumulative release rate curves of drugs in electrospun membranes containing different amounts of synthetic capsaicin

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Structure and Performance Modulation of Self‑Adhesive SIS/C5 Electrospun Membranes for Transdermal Drug Delivery

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