Application of Methanol and Ethanol in Argon-Direct Real Time Mass Spectrometry Analysis

doi:10.11944/j.issn.1000-0518.2017.06.160392

Chinese Journal of Applied Chemistry ›› 2017, Vol. 34 ›› Issue (6): 729-732.DOI: 10.11944/j.issn.1000-0518.2017.06.160392

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Application of Methanol and Ethanol in Argon-Direct Real Time Mass Spectrometry Analysis

ZHOU Feng^a^b,LIU Shu^a,LIU Zhiqiang^a,SONG Fengrui^a^*()

^aNational Center of Mass Spectrometry in Changchun,Jilin Province Key Laboratory of Chinese Medicine Chemistry and Mass Spectrometry,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China
^bUniversity of the Chinese Academy of Sciences,Beijing 100039,China

Received:2016-09-28 Accepted:2017-01-17 Published:2017-05-31 Online:2017-05-31
Contact: SONG Fengrui
Supported by:
Supported by the National Natural Science Foundation of China(No.21673219, No.81373952)

Abstract

Abstract:

In this research, argon was used as the running gas in direct analysis in real time mass spectrometry instead of helium in order to reduce the cost of experiment. Methanol and alcohol as reactive reagents improve the ionization efficiency of analytes and expand the application of Ar-DART-MS. This is because the above reagents play important roles as the medium of the energy transferring and the domor of proton in Ar-DART-MS analysis. Through the analysis of background signal from methol and alcohol as reactive reagents in Ar-DART-MS and their affect on sample ionization, the application scope of methanol and alcohol as reactive reagents in Ar-DART-MS was discussed. Some possible characteristic reactions were also explored. The validity of this method was verified by the analysis of reserpine.

Key words: direct analysis in real time mass spectrometry, argon, methanol, alcohol

ZHOU Feng, LIU Shu, LIU Zhiqiang, SONG Fengrui. Application of Methanol and Ethanol in Argon-Direct Real Time Mass Spectrometry Analysis[J]. Chinese Journal of Applied Chemistry, 2017, 34(6): 729-732.

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Application of Methanol and Ethanol in Argon-Direct Real Time Mass Spectrometry Analysis

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