Synthesis, Structures and Properties of Tris(o-methylbenzyl)tin Thiosalicylate and Di(m-fluorobenzyl)tin Thiosalicylate

doi:10.11944/j.issn.1000-0518.2017.02.160183

Chinese Journal of Applied Chemistry ›› 2017, Vol. 34 ›› Issue (2): 163-171.DOI: 10.11944/j.issn.1000-0518.2017.02.160183

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Synthesis, Structures and Properties of Tris(o-methylbenzyl)tin Thiosalicylate and Di(m-fluorobenzyl)tin Thiosalicylate

ZHANG Fuxing(),KUANG Daizhi,LI Xuanjie,FENG Yonglan,WANG Jianqiu,YU Jiangxi,JIANG Wujiu,ZHU Xiaoming

Key Laboratory of Functional Organometallic Materials of Hengyang Normal University,College of Hu'nan ProvinceDepartment of Chemistry and Material Science,Hengyang Normal University,Hengyang,Hu'nan 421008,China

Received:2016-05-03 Accepted:2016-09-28 Published:2017-01-18 Online:2017-01-18
Contact: ZHANG Fuxing
Supported by:
Supported by Hu'nan Province University Innovation Platform of Open Fund Project(No.15K017, No.14K014, No.13K105), Hu'nan Provincial Natural Science Foundation of China(No.13JJ3112), Scientific & Technological Projects of Hu'nan Province(No.2014NK3086), Aid Programs for Science and Technology Innovative Research Team in Higher Educational Institutions of Hu'nan Province and the Key Discipline of Hu'nan Province, and Project Funding for Research and Innovation Experiment of University Students in Hu'nan Province, the Scientific Research Fund of Hu'nan Provincial Education Department of China(No.15C0199, No.15C0200)

Abstract

Abstract:

Tris(o-methylbenzyl)tin thiosalicylate(1) and di(m-fluorobenzyl)tin thiosalicylate(2) have been synthesized. Crystal structures of the complexes were determined by X-ray diffraction. Crystal 1 belongs to the triclinic space group Pī with a=1.00221(5) nm, b=1.48934(8) nm, c=1.71789(9) nm, α=78.3120(10)°, β=85.6560(10)°, γ=80.2580(10)°, V=2.4725(2) nm³, Z=2, D_c=1.371 g/cm³, μ(MoKα)=10.91 cm^-1, F(000)=1040, R₁=0.0439, wR₂=0.1119. Crystal 2 belongs to the monoclinic space group P2₁/n with a=1.17827(5) nm,b=2.11945(9) nm,c=1.55970(7) nm,β=93.4510(10)°,V=3.8880(3) nm³,Z=4,D_c=1.671 g/cm³,μ(MoKα)=14.53 cm^-1,F(000)=1936,R₁=0.0323,wR₂= 0.0927. The tin atoms in complexes 1 and 2 have four coordinates in a distorted tetrahedral configuration and five coordinates in a distorted trigonal bipyramidal configuration, respectively. Further more, the thermal stability and electrochemical and anticancer activity of the complexes were tested. The results show that complexes 1 and 2 are stable below 152 ℃ and below 195 ℃, respectively, and show irreversible redox process. Complexes 1 and 2 display in vitro anti-tumor activity against five human tumor cell lines Colo205, Hep G2, MCF-7, Hela and NCI-H460, and the anti-tumor activity of complex 2 is higher than that of complex 1.

Key words: tris(o-methylbenzyl)tin thiosalicylate, di(m-fluorobenzyl)tin thiosalicylate, crystal structure, in vitro anticancer activity

ZHANG Fuxing, KUANG Daizhi, LI Xuanjie, FENG Yonglan, WANG Jianqiu, YU Jiangxi, JIANG Wujiu, ZHU Xiaoming. Synthesis, Structures and Properties of Tris(o-methylbenzyl)tin Thiosalicylate and Di(m-fluorobenzyl)tin Thiosalicylate[J]. Chinese Journal of Applied Chemistry, 2017, 34(2): 163-171.

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Synthesis, Structures and Properties of Tris(o-methylbenzyl)tin Thiosalicylate and Di(m-fluorobenzyl)tin Thiosalicylate

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